WebOct 14, 2004 · It has been shown that BIM phosphorylation can promote the degradation of BIM through the proteasome pathway (15, 19). However, in this IL-3-dependent cell, substantial amounts of BIM protein persist after its phosphorylation. Perhaps phosphorylated BIM, which cannot interact with BAX, can also be degraded, providing … WebEnvironmental stress triggers Bim phosphorylation by JNK and results in its dissociation from the dynein complex and increased apoptotic activity. Survival factor induced ERK activation leads to phosphorylation of mouse Bim at Ser55, which inhibits its pro-apoptotic activity and association with Bax (10). O'Connor, L. et al. (1998) EMBO J 17 ...
The oncogenic tyrosine kinase Lyn impairs the pro-apoptotic function of Bim
WebOct 14, 2004 · We show here that the phosphorylation status of BIM controls its proapoptotic activity. IL-3, a hematopoietic survival factor, induces extracellular signal … WebFeb 16, 2012 · This is surprising because BIM L lacks the serine residue equivalent to BIM EL S 69 and the ERK docking domain required for BIM EL phosphorylation. 46 Compared with BIM EL, there was a weaker correlation between levels of BIM L and ERK1/2 phosphorylation, which may reflect a requirement for additional intermediates to … design careers prospects
BIM-Mediated AKT Phosphorylation Is a Key Modulator of …
WebJun 24, 2011 · Bim phosphorylation can decrease its stability or alter its interaction with other proteins to regulate apoptosis ( 21, 22 ). A number of studies have shown that Bim can be phosphorylated by ERK and that such phosphorylation leads to ubiquitination and subsequent degradation in the proteasome ( 16, 17, 21 ). WebApr 10, 2024 · FoxO3a phosphorylation was reported to cause transcriptional inhibition of apoptosis-related genes BIM and PUMA and subsequently inhibit cell apoptosis [17, 36, 37]. In the present study, we showed that Dan treatment was effective to activate the AKT/FoxO3a pathway and downregulated the pro-apoptotic genes BIM and PUMA in the … WebFeb 10, 2024 · Dans les cellules cancéreuses, la localisation nucléaire de FoxO3 quand elle n’est pas exclue par phosphorylation a été largement étudiée comme une protéine cruciale pour son rôle suppresseur de tumeur via la régulation de gènes impliqués dans l’apoptose et l’arrêt du cycle cellulaire comme les protéines BIM et P27. chubby bathing suits for men