WebMar 29, 2024 · Funding Organization Location Grant Number; National Science Foundation (NSF, United States) United States: NSF-DMR-1533958: National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) WebShe is interested in using cryo-EM to investigate how the HIV accessory protein Vif antagonizes APOBEC3 host restriction factors via hijack of the ubiquitin proteolysis pathway. ... Un Seng works between the Cheng lab and Geeta Narlikar’s lab at UCSF to study chromatin and chromatin remodelers. Supported by a National Institute of Health F32 ...
Structures of monomeric and dimeric PRC2:EZH1 reveal flexible …
WebDec 16, 2008 · Although 30-nm chromatin fibers can be routinely observed by cryo-EM in chromatin suspensions in vitro (21, 22), cryo-EM studies of HeLa S3 cells did not reveal this structural feature in mitotic chromosomes . Nevertheless, because the influence of the CTF was not compensated for, it remained unclear whether the absence of 30-nm fibers … WebCryo-EM for Chromatin Remodeling Complex Chromatin remodeling factor is an important component of epigenetic regulation. In eukaryotic cells, ATP-dependent chromatin remodeling factors regulate chromatin structure by altering the assembly, disassembly, and rearrangement of nucleosomes on chromatin, thereby improving the … tribalkingdom.com
Investigating eukaryotic cells with cryo-ET - PMC - National Center …
WebRT @Sveta_Dodonova: An ERC-funded Postdoc position is available in my group @EMBLHeidelberg ! If you are interested in #chromatin, #cryoEM, #tomography and #Archaea ... WebFeb 19, 2024 · (C) Cryo-EM demonstrates that an IDR referred to as the AID in the Spt16 subunit of the FACT chaperone adopts a stable structure and mimics DNA when in complex with a nucleosome. Shown on the left is a representative structure of FACT in complex with the nucleosome (PDBID: 6UPL ), with the AID colored red. WebOur cryo-EM study, which provides nearly complete pseudo-atomic models of all the structural elements within a functional human PIC, has allowed us to define the structural transitions through the processes of DNA engagement by the CC, opening of the transcription bubble in the OC, and initiation of transcription in the ITC. tepeitic hidalgo