Cisplatin apoptosis induction concentration

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August undefined, 2024

WebOct 5, 2014 · Cisplatin is stable under normal temperatures and pressures, but may transform slowly over time to the trans-isomer (IARC 1981, Akron 2009). Cisplatin has a … WebJan 16, 2024 · In the experimental group, with a concentration of 0.1 g/ml of cisplatin, about 37% of the cells were alive and about 6% of the cells had primary apoptosis. More than 42% of the cells had secondary apoptosis and about 14% of the cells had necrosis.

Cisplatin nephrotoxicity: new insights and therapeutic …

WebCisplatin is the most important and efficacious chemotherapeutic agent for the treatment of advanced gastric cancer. Cisplatin forms inter- and intrastrand crosslinked DNA adducts … WebMar 1, 2006 · The chloride ions in cisplatin are particularly important in its action as a drug. They are relatively stable when the drug is outside the cell, where the chloride concentration is normally high. But when the drug gets inside the cell and the chloride concentration drops, cisplatin loses its two chlorides, and they are replaced by water … hover hillsborough county court

Necrotic Concentrations of Cisplatin Activate the Apoptotic Machinery ...

WebSep 18, 2024 · National Center for Biotechnology Information WebAug 16, 2002 · Induction of apoptosis with MMC in the human breast cancer cell line MCF-7. To determine the cytotoxic effect of various anticancer drugs with different mechanisms of action in MCF-7 cells, the ... WebFeb 17, 2024 · It came out that when the concentration of cisplatin was below 2 mg/L, the cell activity was basically above 90%, so the effect of cisplatin on cell activity was small at this time. However, when the concentration of cisplatin was above 2 mg/L, the cell activity was inversely proportional to the concentration of cisplatin. hover hillsborough county

Total alkaloids in Stephania tetrandra induce apoptosis by …

Cytotoxic effects and apoptosis induction of cisplatin-loaded …

WebJul 3, 2024 · A single injected dose of cisplatin has been commonly used in that it is effective and practical at concentrations ranging from 10 to 30 mg/kg, as shown in Table 1. However, this approach is not similar to clinical chemotherapy in which cisplatin is administered as a single intravenous dose every 4 to 6 weeks with as many as six … WebMay 16, 2011 · After these metabolic changes a drastic decrease in cellular impedance occurred at about 10–11 h after exposure to cisplatin ( Fig. 2 C ), which reflects the … hover hillsborough county loginWebCell clones were stained by Giemsa; (c) Induction of apoptosis and necrosis was analysed in untreated LTTs and those treated with IC 50 concentration of cisplatin, IC 50 … hover hillsborough court records

"WebJul 28, 2024 · The present study indicated that cisplatin at the maximum response concentration mediated autophagy through the induction of OH ·, which subsequently … " - Cisplatin apoptosis induction concentration

Cisplatin apoptosis induction concentration

Apoptosis Induction with Combined Use of Cisplatin and Fisetin …

WebOct 13, 2024 · Cisplatin is mainly cleared by the kidney through glomerular filtration and tubular excretion, resulting in a higher concentration of this drug in the kidney than in … WebCisplatin-induced testicular damage is a major obstacle in the application of cisplatin as chemotherapeutic agent. However, it remains as one of the most widel 掌桥科研一站式科研服务平台

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WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in …

WebNov 7, 2024 · Cisplatin efficiently induced cell death in OVCAR-3, OVCAR-4, and IRGOV-1 (>60% cell death) whereas OVCAR-5, OVCAR-8, and A2780 showed <30% apoptotic cells in response to cisplatin. Based on... WebSep 1, 2024 · CDDP had differential effect on proteins expression and induced apoptosis in GC cells. a Western blot shows the effect of CDDP on protein expression in AGS and NCI - N87 cell lines. The expression of tumor suppressor protein 53 increased with CDDP concentration, whilst Akt and NFkB expressions reduced, notice the cleaved PARP …

WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different … WebApr 25, 2014 · The dosage of cisplatin determines whether the cells die by necrosis or apoptosis [30]. In cell culture studies, high concentrations of cisplatin cause necrotic cell death but lower concentrations lead to apoptosis. However,in vivo, cisplatin induces both necrosis and apoptosis [31].

WebThe anticancer drug cisplatin induces cell death by apoptosis. Apoptosis is dependent on cellular loss of potassium ions (K+). We have recently shown that the antifungal drug amphotericin B (enhancin

WebJul 1, 1999 · Treatment of each cell line with IC 90 concentrations of cisplatin yielded clear cleavage of procaspase-3 in the CP70 and C30 cells, whereas we were still unable to … hover hillsclerk.com probateWebWe previously described that blocking ALDH activity enhances the induction of apoptosis, especially in ovarian cancer stem cells treated with chemotherapeutic agents. ... According to Table 1, the combination of cisplatin at the concentration of 0.4 µM, which is a reduction by 51.06-fold from 22 µM, with paclitaxel at 0.03 µM, ... hover hold exerciseWebOct 16, 2006 · Cisplatin is a broad-spectrum anticancer drug that is also widely used in experimental studies on DNA damage-induced apoptosis. Induction of apoptosis … hover home hillsclerk.comWebApoptosis inducers act on several apoptosis-related proteins to promote apoptotic cell death. Depending on the agent selected and the concentrations used, apoptotic events … hover helmet storage instructionsWebJul 5, 2024 · The obtained results from flow cytometry analysis showed that the rate of apoptosis was 4.26% in the cells treated with cisplatin, 38.69% in the cells treated with cisplatin-IONPs and 46.33% in the cells treated with cisplatin-IONPs-chitosan after 24 h (Fig. 3) and also showed that the rate of necrotic cells treated with cisplatin was … hoverhofweg hout blerickWebApr 28, 2011 · Cisplatin is a chemotherapeutic drug widely used in the treatment of a variety of cancers, including sarcomas, lymphomas, and some carcinomas such as small … how many grams in 1 tsp chili powderWebWe have treated four prostate tumor cell lines, DU-145, PC-3, LNCaP and 22RV1 with various concentrations of cisplatin in order to check for influence on viability and for onset of apoptosis induction. At a cisplatin concentration of 20 microM, 22RV1 and DU-145 cells showed approximately 22% and 18% and PC-3 and LNCaP cells showed … hover help in powerpoint