Cisplatin renal injury

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August undefined, 2024

WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … WebMay 5, 2024 · Here, we found that bisdemethoxycurcumin (BDMC), a natural compound, can significantly attenuates cisplatin-induced apoptosis of renal tubular epithelial cells in …

Cumulative DNA damage by repeated low-dose cisplatin injection …

WebRenal injury induced by cisplatin primarily occurs in proximal tubules, 1 where the tubular injury causes a decrease in the glomerular filtration rate. 2 Because of this decrease in … WebMar 23, 2024 · For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10-20% of all cancer patients. … shanghai tattoo astoria

Neferine mitigates cisplatin-induced acute kidney injury in mice …

WebDec 12, 2024 · PSTPIP2 administration suppressed kidney injury in response to cisplatin treatment, suggesting that PSTPIP2 can be a part of a useful therapeutic strategy for … WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different … WebFeb 5, 2010 · It is the urinary concentrations of furosemide that determine its diuretic effect. The severity of acute kidney injury has a significant effect on the diuretic response to furosemide; a good ‘urinary response’ may be considered as a ‘proxy’ for having some residual renal function. shanghai taste rockville menu

Macrophages in Kidney Injury, Inflammation, and …

Cisplatin-induced renal injury is independently mediated by

WebJul 7, 2016 · This study presents data on renal outcomes across multiple tumor types in 821 adults. We report on incidence of AKI, initial and long-term changes in eGFR after … WebOct 1, 2024 · Indepth analyses of this intra-animal variability revealed C-C motif chemokine ligand 2 as a marker of cisplatin-induced kidney injury through correlation studies. In … shanghai tax calculatorWebA known complication of cisplatin administration is acute kidney injury (AKI). The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often necessitates … shanghai tattoo festival

"WebThis includes acute kidney injury as well as tubular injury resulting in electrolyte wasting. Extensive research has found that cisplatin entry into a cell is facilitated by a number of … " - Cisplatin renal injury

Cisplatin renal injury

Rapamycin Perfluorocarbon Nanoparticle Mitigates …

WebRenal injury induced by cisplatin primarily occurs in proximal tubules, 1 where the tubular injury causes a decrease in the glomerular filtration rate. 2 Because of this decrease in the glomerular filtration rate, the elimination of cisplatin is delayed in patients with cancer, and, as a result, tubular and glomerular injuries subsequently develop. WebNov 3, 2024 · The kidney injury caused by cisplatin can present in a variety of ways. As it was clearly proved in some researches, the most serious and common damage induced by cisplatin is acute kidney injury (AKI) which occurs in 20–30% of patients, following a single injection of cisplatin [ 4 ].

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WebSurgery-induced renal ischemia and reperfusion (I/R) injury and nephrotoxic drugs like cisplatin can cause acute kidney injury (AKI), for which there is no effective therapy. … WebApr 25, 2014 · Most of the cisplatin is trapped within the renal cortex [13, 22]. The concentration of cisplatin in the proximal tubular cells is 5 times higher than the serum …

WebDec 21, 2024 · Myo-inositol, a carbocyclic sugar, is believed to be relevant to renal pathobiology since the kidney is the major site for its catabolism. Its role in acute kidney … WebAug 17, 2024 · Thirty percent of patients treated with cisplatin develop acute kidney injury, and all patients are at risk for long-term impacts on kidney function. There are currently no Federal Drug Administration-approved agents to prevent or …

WebApr 3, 2024 · As a result, renal injury is the most serious adverse effect restricting the application of cisplatin [ 4 ]. The prevalence of CP-induced acute kidney injury (CP-AKI) is approximately 31% to 68% in patients using cisplatin [ 5 ]. CP-AKI is characterized by tubular damage and acute renal dysfunction [ 6 ]. WebCisplatin is a potent antineoplastic agent derived from platinum and commonly used in the treatment of head and neck, bladder, ovarian, and testicular malignanc Cisplatin …

WebJan 3, 2024 · - Conventional cytotoxic agents dose reduce kidney impairment - Molecularly targeted agents dose reduce kidney impairment - NCI CTCAE v5 acute kidney injury, …

WebOct 1, 2024 · Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer. However, its dose-limiting side effect is nephrotoxicity leading to acute kidney … shanghai tattoo folsomWebMar 29, 2024 · Mechanisms of Cisplatin-Induced Acute Kidney Injury: Pathological Mechanisms, Pharmacological Interventions, and Genetic Mitigations Cancers (Basel). … shanghai tax calculator 2022WebMay 1, 2008 · Cisplatin may also induce injury in renal vasculature and result in decreased blood flow and ischemic injury of the kidneys, contributing to a decline in glomerular filtration rate. These events, together, culminate in the loss of renal function during cisplatin nephrotoxicity, triggering acute renal failure. shanghai tax bureau for foreignersWebThe cisplatin-treated rats exhibited acute structural damage characterized by tubular necrosis, swelling and tubular dilation, extensive epithelial vacuolization, and hyaline casts in renal... shanghai taste menu rockvilleWebMay 1, 2015 · Cisplatin causes direct necrosis and apoptosis of proximal tubule cells but also induces a series of inflammatory changes that mediate kidney injury. In vitro cisplatin induced enhanced expression of TLRs … shanghai taxi companiesWebJul 31, 2014 · Although the severity of cisplatin-induced nephrotoxicity is reduced following genetic or pharmacologic knockout of Oct1 and Oct2, renal tubular damage is not completely abolished. This suggests the existence of a secondary pathway that contributes, independently of Oct1/Oct2-mediated renal tubular drug uptake, to cisplatin-induced … shanghai taxi serviceWebMar 29, 2024 · Cisplatin-Induced Acute Kidney Injury: Role of the Immune System . Inflammatory pathways have been linked to major pathophysiological mechanisms … shanghai taxi price