Cryptic transcripts
WebMar 19, 2009 · The authors then predicted the occurrence of cryptic transcripts by comparing the ratio of probe values measured at the 5′ end of the gene to the ratio of … WebJun 26, 2024 · The activation of cryptic TSSs significantly alters transcription of nearby TSSs, including those of genes important for development and stress responses. Our …
Cryptic transcripts
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WebWe also focus on the molecular mechanisms that cells exploit to prevent cryptic transcripts from interfering with the expression of protein-coding genes. Finally, we summarize data … WebCryptic transcription is widespread and generates a heterogeneous group of RNA molecules of unknown function. To improve our understanding of cryptic transcription, we investigated their transcription start site (TSS) usage, chromatin organization, and posttranscriptional consequences in Saccharomyces cerevisiae We show that TSSs of …
WebMar 19, 2009 · The authors then predicted the occurrence of cryptic transcripts by comparing the ratio of probe values measured at the 5′ end of the gene to the ratio of probe values at the 3′ end of the gene. A higher ratio at the 3′ end indicated an aberrant transcript that initiated somewhere downstream of the natural 5′ promoter. Based on the set ... WebJul 27, 2024 · In a low-immunogenic tumor model, DNA demethylation upregulates cryptic transcript expression in a HIF-dependent manner, causing immune activation and reducing tumor growth. Conclusions Our data elucidate the mechanism underlying cell-type-specific responses to hypoxia and suggest DNA methylation and hypoxia to underlie tumor …
WebFeb 7, 2024 · Genetic and pharmacological DNA demethylation, but also cancer-associated DNA hypomethylation, expose these binding sites, inducing HIF-dependent expression … WebAug 2, 2024 · Researchers have discovered that a cellular phenomenon called cryptic transcription, which had been previously described and linked to aging in yeasts and …
WebAug 22, 2003 · By this model, in an spt6 mutant, RNA Pol II elongation causes a global disruption of chromatin structure, creating a permissive chromatin environment for transcription initiation from cryptic sites that fortuitously contain a TATA element and proximal initiation site. Other investigators have also proposed that the passage of RNA …
WebOct 21, 2024 · The Duchenne muscular dystrophy (DMD) gene has a complex expression pattern regulated by multiple tissue-specific promoters and by alternative splicing (AS) of the resulting transcripts. Here, we used an RNAi-based approach coupled with DMD-targeted RNA-seq to identify RNA-binding proteins (RBPs) that regulate splicing of its skeletal … dynamic house the greatest rock and roll hitsWebMay 15, 2024 · We found polyadenylated cryptic transcripts running both sense and anti-sense relative to genes in this mutant. Cryptic promoters were enriched for TATA boxes, suggesting that the underlying DNA sequence defines the location of cryptic promoters. While intragenic sense cryptic transcripts terminate at the terminator of the genes that … crystal\u0027s catering herrinWebFeb 22, 2024 · Figure 5: Transcripts produced from intragenic cryptic starting sites are polyadenylated, stable and ribosome-associated RNAs. a, Box plot of the ratio between normalized poly (A) RNA-seq RPKM... crystal\\u0027s calumet city ilcrystal\\u0027s cateringWebApr 23, 2015 · Early termination of these transcripts (named CUTs for cryptic unstable transcripts) is coupled with the recruitment of the Trf4-Air2-Mtr4 (TRAMP) complex and the Rrp6-containing nuclear RNA-exosome for rapid degradation ( Wyers et al., 2005; Davis and Ares, 2006; Tudek et al., 2014 ). dynamichr/isolvedWebOct 9, 2024 · Cryptic transcripts were more strongly activated than wildtype transcripts from these genes (Supplementary Figure S4D), implying cryptic transcription contributed to the upregulation of these genes. Intriguingly, transcriptional activation of cryptic transcripts fused with TEs was stronger than other cryptic transcripts (Supplementary Figure S4E). dynamic hot yoga brightonWebAug 2, 2024 · Cryptic transcription is elevated with age in yeast and nematodes and reducing it extends yeast lifespan, though whether this occurs in mammals is unknown. … dynamic href in html