WebFeb 10, 2024 · Granulocyte Colony Stimulating Factor (CSF2) acts on the GM-CSF receptor to modulate inflammation [53,54]. Although it is shown to be a pro-inflammatory agent in the literature, it may have neuroprotective properties . The upregulation of CSF2 by EGCG may heighten the microglia’s immunosurveillance properties to allow for a neuro-defensive ... Web2.1. Mice. The B6.SJL-Ptprc a Pepc b /BoyJ (Stock No: 002014/B6 CD45.1), Csf2rb −/− and Csf2 −/− mice used in this study were bred in Cincinnati Children’s Hospital Research Foundation (CCHRF) vivarium using protocols approved by the institutional animal care and use committee (IACUC) at Cincinnati Children’s Hospital Medical Center.In this study, …
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