WebApr 10, 2024 · To investigate the role of glutamate in psychosis, we employ functional magnetic resonance spectroscopy at an ultra-high magnetic field (7T) and emplo… WebBriefly, the dopamine hypothesis attributes hyperdopaminergic function as a possible cause of schizophrenia, whereas the glutamate hypothesis proposes a hypofunctional glutamate system. There is substantial evidence for both hypotheses, but some of the most impressive data are from observations that certain classes of drugs can produce ...
Schizophrenia and obesity: May the gut microbiota serve as a link …
WebSep 28, 2011 · Glutamate is the primary excitatory neurotransmitter in mammalian brain. Disturbances in glutamate-mediated neurotransmission have been increasingly … WebNov 26, 2013 · The glutamate hypothesis of schizophrenia, proposed over two decades ago, originated following the observation that administration of drugs that block NMDA glutamate receptors, such as ketamine, could induce schizophrenia-like symptoms. Since then, this hypothesis has been extended to describe how glutamate abnormalities may … issues in psychological testing
Chapter 18: Antipsychotics – Drugs and Behavior
WebJun 1, 2013 · The glutamate hypothesis, which posits an upstream cause for dopaminergic abnormalities, suffers the same problem because it makes the same PET scan predictions. ... In summary, the serotonin hypothesis of schizophrenia explains the origin of positive and negative symptoms, the relationship or schizophrenia to stress, cortical atrophy ... WebThe dopamine hypothesis of schizophrenia has been ncurochemically preeminent, for 40 years. 58,59 It received support from various postmortem findings of increased dopamine content and higher densities of dopamine D 2 receptors in schizophrenia. 60 However, despite its longevity, there is still no consensus as to precisely what the dopamine ... WebThe glutamate hypothesis of schizophrenia is centered on a deficiency in activity of glutamate at the glutamate synapse, especially in the prefrontal cortex [48,49]. In many … ifr finish up