WebApr 15, 2024 · They reported a 1-year incidence of myopathy in German incident statin users of 1.93% (= 10,250 / 531,672). Thus, one could prevent 0.00475 / 0.00818 * 10,250 = 5960 [95% CI 4469–7450] myopathy cases each year only in Germany, if new statin users started simultaneously with SGLT-2 inhibitor therapy. WebVery rarely, statins can cause life-threatening muscle damage called rhabdomyolysis (rab-doe-my-OL-ih-sis). Rhabdomyolysis can cause severe muscle pain, liver damage, kidney failure and death. The risk of very serious side effects is extremely low, and calculated in a few cases per million people taking statins.
Author’s Reply to Kuss and Rathmann’s Comment on: “Drug-Drug ...
WebAug 29, 2007 · The etiology of statin-induced myopathy is not well understood, but potential contributing mechanisms include decreases in mevalonate pathway products, … Webbases [3]. Specically, the incidence proportion cannot be accurately calculated due to the lack of a denominator (i.e., population at risk) and because the numerator is derived ... inhibitors and statins on myopathy risk were also made by Kuss and Rathmann, despite dierence in the properties of these two antihyperglycemic classes [6 ]. how many subjects are there in neet
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WebJul 1, 2024 · STATIN INTOLERANCE: MYOPATHY. While the benefits and safety profile of statin therapy are clear, adverse effects such as statin-related myopathy remain elusive, posing diagnostic and therapeutic challenges. Statin intolerance is widely reported in clinical practice, often leading to its discontinuation. ... WebFeb 12, 2024 · Although the risk of myopathy is unknown, rosuvastatin exposure (area under the concentration-time curve (AUC)) was 144% greater in those with the c.421AA genotype than the c.421CC genotype (wild type); 31 thus, the recommendation is based primarily on pharmacokinetic data. WebJan 27, 2024 · The incidence of myopathy was highest with Simvastatin 40 mg (50%) and lowest with Fluvastatin XL 80 mg (8%) and Rosuvastatin 10 mg (10.8%). Conclusions The overall incidence of myopathy in... how did the us open trade with the japanese